Tech Transfer


1. Fast hydrolysis process 快速水解木质纤维素技术 (US patent#: 8268126, 2012; US patent#: 9115215, 2015; US patent#: 9243303, 2016; Chinese patents: ZL200710141265.3, 2013; ZL201010297515.4, 2012)专利转让:

Lignocellulosic biomass (wood, grass) is completely solubilized in hot water to become “wood solution” that is subsequently hydrolyzed to sugars in seconds for biofuel production.

I (Prof. Fang) am the inventor of “fast hydrolysis” process (U.S. patent #: 8268126) entitled “Method, equipment and applications for fast complete dissolution and hydrolysis of lignocellulosic biomass”.  The patent was issued on September 18, 2012 for technology that provides a simple and low-cost method to fast, completely and continuously dissolve and hydrolyze lignocellulosic biomass with great potential for a novel biorefinery.

Briefly stated, my invention comprises method, equipment and applications for fast complete dissolution and hydrolysis of lignocellulosic biomass continuously.  The unique features of my invention are simple, complete, continuous and fast dissolution and hydrolysis of actual lignocellulosic biomass (wood or grass). The advantages of my invention offer a simple, fast and low-cost way of applying it on a large commercial scale because of the unique features of the invention.

I have 23 years experiences in bioenergy research at top universities and institutes around the world. In my previous work, I found for the first time that cellulose could be completely dissolved in water at temperature above 320 oC and became a ‘cellulose solution’, which made it possible to build up a continuous flow reactor for the rapid hydrolysis of cellulose. However, the separating of pure cellulose from actual biomass (e.g., wood) is complicated and costly. It is difficult for the solubilization and hydrolysis of pure cellulose to be commercialized. Thus, I invented a ‘fast hydrolysis’ process of actual lignocellulosic biomass (wood) by adding 0.8 wt% Na2CO3, actual wood without pretreatment can be completely dissolved upon fast-heating (7~16°C/s) to form a ‘wood solution’ at 329-367 oC at short reaction times (0.7-2 s). The ‘wood solution’ can be rapidly (ca. 15 s) hydrolyzed to sugars/sugar oligomers under homogeneous conditions. The patent is the latest development in my 23-year effort in the study of biomass hydrolysis process, aimed at a simple, fast and low-cost method for a novel biorefinery. The ‘fast hydrolysis’ process will be the technological key to economic utilization of abundant lignocellulosic biomass as viable feedstocks for the production of industrial sugar, ethanol and chemicals. My pioneering work opens the door, for the first time, to the possibility of developing industrial-scale technology at competitive cost for producing biofuels and value-added products from lignocellulosic biomass based on the ‘fast hydrolysis’ process in a flow reactor.

You may also visit the web for more detailed information about the:  U.S. patent #: 8268126. I am seeking to sell or license the patent rights, or other forms of collaboration to commercialize it. If you are potentially interested in the U.S. patent #: 8268126. Please contact me anytime at Tel: 86-25-58606657; E-mail:;;

快速水解木质纤维素技术(US patent#: 8268126, 2012; US patent#: 9115215, 2015; US patent#: 9243303, 2016; Chinese patents: ZL200710141265.3, 2013; ZL201010297515.4, 2012)专利转让:

方真教授发明:不经任何预处理(节能),加微量的碱(环保),只需短短几秒钟(快速),100 %的木质纤维素(木材或草)可以快速完全溶解于水中,这样木质纤维素溶液象液体石油一样很易加工,如快速水解于高压热水当中。首先,当木质纤维素颗粒和水快速加热时,木质纤维素快速完全溶解,随后立即在高压热水中水解成糖类。方真研究员发明并建立了一套可操纵连续化水解装置,可快速、连续、大规模地水解木材来生产糖类,从而使实现工业化生产成为可能。相关的研究申请了专利:

(1) ZL200710141265.3:

(2) US patent#: 8268126:



2. Synthesis of amides from lignocelluloses (以木质纤维素为原料合成酰胺): A protocol is developed that shows in situ formed N-formyl quasi-catalytic species afford highly selective synthesis of formamides or amines with controllable levels from a variety of aldehyde- and ketone-derived platform chemical substrates (that can be easily produced via our patented “fast hydrolysis” process from lignocelluloses and subsequent catalytic conversions) under solvent-free conditions. Up to 99% yields of mono-substituted formamides are obtained in 3 min. The C-N bond formation and N-formyl species are prevalent in the cascade reaction sequence. Kinetic and isotope labeling experiments explicitly demonstrate that the C-N bond is activated for subsequent hydrogenation, in which formic acid acts as acid catalyst, hydrogen donor and as N-formyl species source that stabilize amine intermediates elucidated with density functional theory. The protocol provides access to imides from aldehydes, ketones, carboxylic acids, and mixed-substrates, requires no special catalysts, solvents or techniques and provides new avenues for amination chemistry. (Patent: PCT/CN2019/098614, 2019; Nature Communications, 10, 699, 2019, Green Chem,, 2020).

3. Magnetic solid catalyst for biodiesel production (一种用于生物柴油制备的碳基磁性固体催化剂合成方法) (Chinese patents: ZL201410764721.X, 2016; ZL201420785283.0, 2015; ZL201220038727.5, 2012; ZL201110334924.1, 2013).

A cheap and high active magnetic heterogeneous catalyst (Na2SiO3@Fe3O4/C) was prepared for the production of biodiesel from oils with high acid value (AV).

With the catalyst and assisted by US, soybean biodiesel yield reached > 90% in only 20 min (or at 318 K) and 97.9% under the optimal conditions. It was easily magnetically separated for 5 cycles with 94.9% recovery rate and biodiesel yield > 80% with both US and MS. The catalyst transesterified Jatropha oil with biodiesel yields of 94.7%, 93.2% and 83.5% at AV of 1.3, 4.8 and 7.3 (mg KOH/g) with US, and was cycled 5 times with yield > 70% at AV of 4.8 assisted by US and MS. High biodiesel yield (90.7%) was still achieved from high AV oil (4.8) at low US energy density (0.1 W/mL) and MS. The catalyst combined with US and MS can find practical application for direct production of biodiesel from oils with high AV.

Magnetically recyclable catalysts are synthesized to produce biodiesel in a compacted flow reactor without discharging liquid catalyst wastes. Short reaction time is achieved by using microwave and ultrasound.

(URL:, Patented reactor license transferred to Shandong Yikang pharmaceutical co. LTD on Oct. 23, 2018).


4. One-step and low/room temperature synthesis of liquid biofuels from carbohydrates (Patents: PCT/CN2017/106729, CN 106861754 A). 

Nanocatalysts were syntheisized to catalyze the high yield production of liquid biofuels (e.g., methyl levulinate, γ-valerolactone, 2,5-dimethylfuran, methylfuran) at low temperatures directly from carbohydrates (e.g., sugars, cellulose). It is found that 95% 2,5-dimethylfuran yield was obtained from fructose at 110 °C, 99% 2,5-dimethylfuran yield from 5-hydroxymethylfurfural and 97% 2-methylfuran yield from furfural were even achieved at room temperature (25 °C) when polymethylhydrosiloxane was used as H-donor. Therefore, liquid biofuels (e.g., 2,5-dimethylfuran) can be produced from sugars via the hydrolysis of lignocellulosic biomass that is easy for commercial applications in simple and inexpensive reactors.



Tel: 86-25-58606657